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KMID : 0390019930030010032
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Pediatric Allergy and Respiratory Disease
1993 Volume.3 No. 1 p.32 ~ p.40
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Effect of EPA/DCHA supplementation on the clinical course and the airway responses to methacholine and allergen in the asthmatic children
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Abstract
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I have studied the effect of dietary fish oil supplementation(1.8gm/day of eicosapentaenoic acid and 1.2gm/ day of docosahexaenoic acid) for 12 weeks on the clinical course, and the methacholine and allergen induced airway responses in 12
asthmatic
children. Diurnal peak expiratory flow, symptom scores, and bronchodilator use were measured for clinical course assessment, and methacholine and allergen bronchial provocation tests were performed before and after dietary supplementation of EPA
/
DCHA.
There was no significant change in any of clinical measurements. However, the magnitude of methacholine induced bronchoconstriction and allergen induced early or late asthmatic responses were significantly attenuated following EPA / DCHA.
Although the above results indicated that fish oil supplementation has little effect on the clinical severity of asthma, they may have some therapeutic implication insofar as EPA / DCHA attenuate the airways response to various stimuli.
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